Vol. 5, Issue 1, Part A (2023)

The study aimed to show the relation between the level of the Adropin hormone and diabetic nephropathy patients, in addition to measuring the lipid profile, as well as the level of uric acid, creatinine, and urea. Diabetic nephropathy (DN) is the main risk parameter for a diversity of adverse prognosis results because it affects directly the cardiovascular system, particularly, in diabetic nephropathy patients, and so far it has been shown that natural products have a significant impact on preventing the growth of DN. Adropin hormone is a peptide discovered in 2008 by Kumar et al which involves 76 amino acids. Adropin is effective in lowering blood sugar and improving insulin resistance. The study included ((60) blood samples for people with diabetic nephropathy and both sexes, their ages ranging between (35-80) years, which were taken from the people who visited Kirkuk Hospital. The outcomes of the work displayed a significant increase in the possibility (0.001 (P ≤) level in the hormone adropin and the level of creatinine, urea, and uric acid in the patients with diabetic nephropathy compared to the normal ones. The results also displayed a major increase in the lipid profile (cholesterol, triglycerides, LDL-C, VLDL-C), and a large decrement in the concentration of HDL-C in the group of people with diabetic nephropathy compared with the healthy ones.